Signal Transduction Reagents and Kits
Apexbio Technology LLC Aurora Kinase Inhibitor III 879127-16-9 1mg
Aurora Kinase Inhibitor III (CAS 879127-16-9) is a selective small molecule inhibitor targeting Aurora A kinase It acts by binding to the ATP-binding site of Aurora A thereby suppressing its enzymatic activity with an IC50 of 42 nM The compound exhibits substantially lower inhibitory potency against epidermal growth factor receptor (EGFR) with an IC50 greater than 10 M Aurora Kinase Inhibitor III serves as a useful chemical probe for investigating Aurora A-mediated processes including mitotic regulation cell cycle progression and associated signaling pathways and supports studies exploring the role of Aurora A in oncogenesis
Montana Molecular Green Ratiometric Cilia-Targeted cADDis cAMP Sensor Kit D0211G, 10mL, CMV
Measure real-time cAMP signaling kinetics in the primary cilia with this live cell fluorescent assay. Add cADDis to your cells and measure robust signals the next day on a fluorescence imaging system. Decreasing green fluorescence indicates ciliary cAMP increase. Constitutively expressed cytosolic red fluorescence can be used for ratiometric measurements. This assay is genetically encoded and packaged in BacMam for efficient delivery to cilia in most cell types, including many primary and iPSC-derived cells.
Waters Corporation Upgrade Kit, Transducer BGM, for HPLC Systems
This upgrade kit is designed to update early 2545 Binary Gradient Modules in HPLC systems. It provides a newer style pressure transducer with a die-cast housing, along with tubing assemblies and an adapter, to replace older, round version transducers.
- Provides one pressure transducer and tubing assemblies.
- Updates early 2545 Binary Gradient Modules.
- Features a newer style transducer with a die-cast housing.
- Replaces older, round version transducers.
- Includes an adapter for installation to the pump head.
- Suitable for HPLC systems.
- Units per package: 1.
Cell Biolabs Inc ViraDuctin™ Retrovirus Transduction Kit, 40 transductions
The rate at which retroviral vectors bind to and infect cells is mostly controlled by diffusion. During retrovirus infection, only a small fraction of the retroviral vectors can transduce target cells. Virion adsorption is the limiting step of this process. The use of polycations, such as Polybrene, is standard in many retroviral infection protocols owing to the observations of improved infection efficiency. Its mechanism of action is thought to involve neutralization of electrostatic repulsion between virion and cell membranes, enhancing attachment. ViraDuctin™ Retrovirus Transduction Kit is a proprietary formulation for the transduction of retrovirus. After forming a complex with retrovirus in culture medium, the ViraDuctin™ reagents typically provide higher transduction efficiency in many cell types compared to reagents such as Polybrene. It is ideal for transduction of nonpermissive cells such as primary cells and stem cells. 40 transductions.
Medchemexpress LLC Syk-IN-4 | 2932264-95-2 | 98.0% | C21H25N9O | 10MG
Potent, selective, orally bioavailable spleen tyrosine kinase (SYK) inhibitor with sub-nanomolar potency (IC50 = 0.31 nM). Characterized for in vivo oral exposure and intended for research into autoimmune disorders and hematologic cancers. Supplied as a high-purity white to off-white solid with documented solubility and storage recommendations.
- Sub-nanomolar inhibitory potency against SYK (IC50 = 0.31 nM).
- Orally bioavailable with demonstrated oral exposure in rodent models.
- High purity suitable for biochemical and cellular assays.
- Well-characterized solubility protocols for in vivo formulation.
- Stable under recommended storage conditions.
Revvity Health Sciences Inc HTRF cAMP Gs HiRange Detection Kit Standard, 10 Vials
HTRF cAMP Gs HiRange Detection Kit Standard, 10 Vials
Enzo Life Sciences Lysophosphatidic acid, (5mg), CAS Number: 325465-93-8
LPA receptor ligand. Lysophosphatidic acid (LPA) is a multifunctional intercellular phospholipid messenger. LPA stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes. It acts as a proliferative and anti-apoptotic factor. Ligand for LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors. It also inhibits differentiation of neural stem cells into neurons. Alternative Name: 1-Oleoyl-lysophosphatidic acid . sodium salt. Formula: C21H40O7P . Na. MW: 458.5. CAS Number: 325465-93-8. Purity: ≥98% (TLC). Appearance: Waxy solid. Solubility: Soluble in water (5 mg/mL with sonication) or DMSO (0.5 mg/mL warm). Use/Stability: Store as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month. Long Term Storage: -20°C
Revvity Health Sciences Inc HTRF Human Phospho-STAT3 (Tyr705) Detection Kit, 50,000 Assay Points
HTRF Human Phospho-STAT3 (Tyr705) Detection Kit, 50,000 Assay Points